Traitwell PGX is a free and informative gene-drug interaction resource tool to help you understand why some drugs work better or worse for you based on your DNA. Use your results to help your healthcare provider help you optimize your medical treatment.Get Started For Free
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"Genomics is helping us choose the right medication at the right dose for each patient."“Pharmacogenomics” - National Human Genome Research Institute
As people become more aware of the role that genetics play in health, they are increasingly interested in using genetic testing to learn more about how they might respond to certain medications.
By testing for specific genetic variants, doctors can get a better idea of which medications may work well for a patient, and which ones may cause side effects. This information can be extremely helpful in making sure that patients get the best possible care.
But a drug-gene interaction test usually requires orders from your healthcare provider. It can also be expensive. Or your healthcare provider might not be aware of how useful a drug-gene interaction test can be.
So why not use DNA data you already paid for?
If you’ve already gotten your DNA tested by 23andMe, AncestryDNA, MyHeritage, Living DNA, or Family Tree DNA, you can upload your raw DNA file to Traitwell PGX to check for known drug-gene interactions.
If you are taking any medications, it is important to discuss drug–gene interactions with your healthcare provider. Drug–gene interactions can affect how well a medication works and whether you are more or less likely to experience side effects.
Knowing about your drug–gene interactions can help your healthcare provider optimize your medication regimen and avoid potential adverse reactions.
The Food and Drug Administration (FDA) continually reviews drug-gene interaction studies to determine whether certain drug are safe and effective for people with different genetic markers. They also look at data to see if certain drugs are more likely to cause side effects in people with certain genes. If the FDA finds that a drug is more likely to cause side effects in people with certain genes, they may require that the drug be labeled with a warning.
Commonly used medications already have FDA-reviewed drug-gene interaction guidance and warning labels, such as pain killers, antidepressants, epilepsy drugs, chemotherapies, cholesterol drugs, among many others.
Traitwell PGX is a free and infromative app that tailors this knowledge to you.
Your healthcare provider currently prescribes drugs based on your age, weight, sex, and whether you are taking other drugs.
But healthcare providers are increasingly taking account of patients’ genetic information as well. Genetic studies have identified gene variants that affect how people respond to certain drugs. In these cases, healthcare providers can select the best medication and dose for each patient.
Traitwell PGX is an app that filters these known drug-gene interactions using your unique DNA so that you can use that knowledge to help you stop bouncing back and forth between different drugs. Instead, you can work better with your healthcare provider to get on the right treatment path for your unique medical needs.
"Pharmacogenomics (sometimes called pharmacogenetics) is a field of research that studies how a person’s genes affect how he or she responds to medications."“Pharmacogenomics” - National Institute of General Medical Sciences
What are drug-gene interactions?
A drug-gene interaction is an association between a drug and a genetic variant that affects how you respond to drug treatment.
Knowing about your drug-gene interactions is like knowing about your drug allergies. If you have a particular allergy, you need to be aware of what drugs you are taking and how they might interact with your body. The same is true for drug-gene interactions. By understanding how your genes interact with different drugs, you can help your healthcare provider help you ensure that you are taking the right drugs for your particular genetic makeup.
How good are Traitwell PGX results for drug-interactions?
Traitwell PGX uses data from direct-to-consumer genetic testing services like 23andMe, AncestryDNA, Living DNA, Family Tree DNA, and MyHeritage. These companies don’t test your whole genome – instead, they only test certain parts of your genome that they think might be important. Different companies test different parts of your genome so your results might vary depending on which service you used.
Our algorithms “fill in” the missing parts using an industry-standard method called statistical imputation and then compare this imputed genome with drug-gene interaction information curated by the FDA, CPIC, and PharmaGKB to produce your customized report.
U.S. Food and Drug Administration:The FDA’s Table of Pharmacogenomic Biomarkers in Drug Labeling lists certain genes that can affect how a person responds to a medication. This information can help doctors choose the right medication and dose for each patient. The table includes information on how different genes can affect a person’s response to medications used to treat conditions such as heart disease, mental illness, and cancer.
Clinical Pharmacogenetics Implementation Consortium:CPIC is a group of experts who provide guidance on how to use genetic information to make decisions about medications. They give recommendations on which tests to order and how to interpret the results. The CPIC also provides education to healthcare providers and patients about pharmacogenetics.
PharmGKBPharmGKB is a publicly available, online resource that provides information on the relationships between genes, medications, and diseases. This resource can be used by healthcare professionals, patients, and researchers to help identify potential drug-gene interactions and tailor medication regimens to individual patients.
Since Traitwell PGX results are based on direct-to-consumer data from providers like 23andMe, they are quite accurate for common genetic variants but not for rare genetic variants. For rare genetic variants, the false-positive rate can be very high. That’s why Traitwell PGX is an educational resource and not medical advice.
Should I change medications or dosage based on my results?
Don’t stop or change your medication without talking to your healthcare provider first. The information in the report is not a substitute for professional medical advice, so you should always talk to your healthcare provider about what clinical-grade tests might be right for you. Direct-to-consumer data from providers like 23andMe is not clinical grade, so your Traitwell PGX results should be used as an educational resource for understanding your personal history with different medications and/or as a conversation starter with your healthcare provider for optimizing your medical treatment. Keep in mind that your response to different medications depend not only on your genetics but also on your age, weight, lifestyle, family history, and other factors.
DISCLAIMER: This is a general health and wellness informational application and is not intended to diagnose or treat any condition. Our algorithms are living and breathing, constantly being updated based on the latest evidence. Please discuss your actual risk with your personal physician.
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